Delhi Capitals are flying high, having won both their matches under new skipper Axar Patel, while CSK have struggled with just one win from three games.
Conway will bolster their top order as Tripathi gets the axe after failing in the first three games.
Faf du Plessis' absence will be a big blow and it remains to be seen if K L Rahul opens the batting for the visitors.
Check out the playing XIs:
Chennai Super Kings: Ruturaj Gaikwad (captain), Rachin Ravindra, Devon Conway, Vijay Shankar, Ravindra Jadeja, Mahendra Singh Dhoni (w/k), Ravichandran Ashwin, Noor Ahmad, Mukesh Choudhary, Khaleel Ahmed, Matheesha Pathirana.
Impact Subs: Shivam Dube, Jamie Overton, Shaik Rasheed, Kamlesh Nagarkoti, Nathan Ellis.
Delhi Capitals: Axar Patel (captain), Jake Fraser-McGurk, K L Rahul (w/k), Abishek Porel, Tristan Stubbs, Sameer Rizvi, Ashutosh Sharma, Vipraj Nigam, Mitchell Starc, Kuldeep Yadav, Mohit Sharma.
Impact Subs: Mukesh Kumar, Karun Nair, Darshan Nalkande, Donovan Ferreira, Tripurana Vijay.