Salomon Rondon dented 10-man Manchester United's top-four challenge with a sharp second-half strike to maintain West Bromwich Albion's Premier League revival on Sunday.
The 26-year-old Venezuela striker controlled Sebastien Pocognoli's cross from the left before burying the ball into the left corner on 67 minutes against an increasingly toothless United, who had lost Juan Mata to a second yellow card on 26 minutes.
The Spain international was booked for not retreating and blocking a quickly-taken free kick before receiving his marching orders two minutes later for kicking Darren Fletcher's shin in a clumsy tackle.
United's first league defeat at The Hawthorns since 1984 kept them sixth in the table, three points behind Manchester City in fourth, while West Brom climbed to 11th with a third win in four league games.