India's challenge in the doubles event at the French Open ended after Leander Paes and his Polish partner Marcin Matkowski were knocked out in the quarter-finals on Wednesday.
The Indo-Polish pair lost to Bob and Mike Bryan 6-7(12), 3-6 at Roland Garros in Paris.
Earlier, Paes's compatriot Rohan Bopanna and his Romanian partner Florin Mergea were knocked out after being handed a straight-set defeat.
Bopanna and Mergea, seeded sixth, went down 4-6, 4-6 to third seeds Ivan Dodig of Croatia and Marcelo Melo of Brazil.
In a lopsided contest, Bopanna and Mergea struggled to handle Dodig and Melo's fine service game.
The Indo-Romanian combine was broken once in the opening set and failed to convert either of the two break-points it earned.
Bopanna and Mergea also committed a couple of double faults.
The second set followed a similar script and once again, Bopanna and Mergea failed to break their opponents.
Dodig and Melo, however, continued to be dominant with their first serve besides converting one of the three break-points they earned to outwit the sixth seeds.
In the junior girls, Karman Kaur Thandi lost her second round match against Dayana Yastremska of Ukraine 3-6, 0-6.