Seventh-seeded elder Venus crushed Agnieszka Radwanska of Poland 6-1, 6-3 to book the rendezvous.
Email this Page | Post a comment | US Open coverage
The sisters are 8-8 in head-to-head matches during their career, and 5-5 against each other on the grand slam stage so this one will bring bragging rights as well as a slot in the semi-finals of the year's last major championship.
"It's tough to play her because she is so good," said Venus, who won their last collision at this summer's Wimbledon final for her fifth singles title at the All England Club.