Golfer Michelle Wie (centre) of the United States watches the first round match between Serena Williams and Mara
Santangelo of Italy on day one of the Australian Open 2007 at Melbourne Park on January 15, 2007.
The former world number one crushed 27th seed Santangelo 6-2, 6-1.
"I can definitely win a third title... I'm not going to sit here and say no," said Williams, who is returning after a four-month injury layoff.
"I'm definitely looking at working my way back more than anything. I feel I have nothing to lose and the only way I can go is up."
Photographs: AFP/Getty Images