Ole Gunnar Solskjaer's side, who had won their last ten away games in the Premier League, stay third on 27 points, a point behind second-placed Leicester.
Images from the soccer matches played across Europe on Saturday.
Atletico Madrid's faint hopes of chasing down runaway Liga leaders Barcelona suffered a fresh blow on Saturday as they were held to a 1-1 draw at home to Girona, meaning they could fall 11 points behind the Catalans by the end of the weekend.
Images from English Premier League matches played on Sunday.
A round-up of Saturday's action in the Premier League.
Leicester City's Kelechi Iheanacho scored two poacher's goals as they beat Manchester United 3-1 in their FA Cup quarter-final on Sunday to set up a last-four clash against Southampton.
Real Madrid ensured top spot in La Liga at the midway point of the season when Cristiano Ronaldo struck twice in a 3-0 win at Getafe on Sunday before Lionel Messi's hat-trick helped Barcelona to a 4-0 victory at Deportivo La Coruna.
A round-up of Saturday's matches in the English Premier League.
But for third-placed Spurs, who trail leaders Manchester City and Liverpool by five points, this may prove to be a loss that leaves them with too much ground to make up.
In other European football action Real Madrid were left frustrated after a goalless draw against Athletic Bilbao in their La Liga match on Sunday.
Spain's biggest selling sports daily Marca summed it up in Monday's headline after Barcelona wrapped up a fifth La Liga title in seven years and their 23rd overall on Sunday: 'Messi's League'.
Tottenham Hotspur's status as Premier League title chasers was seriously harmed on Saturday as they fell to a first defeat in seven league games, losing the lead to go down 3-1 at home to Wolverhampton Wanderers.
Valencia climbed above Atletico Madrid and Sevilla into third in La Liga when Alvaro Negredo came off the bench to score a late winner in a 3-2 home victory over his former club Almeria on Saturday.
Two goals from Arda Turan and one from Lionel Messi gave Barcelona a 3-0 win over Sevilla in the Spanish Super Cup second leg on Wednesday to seal a 5-0 aggregate victory.
France earned a rollercoaster 4-2 home win over Croatia in an entertaining top-tier Nations League Group 3 match, while England were held to a 0-0 draw by Denmark in an uninspiring game.
Sergio Ramos made amends for his untimely own goal last week at Sevilla by scoring twice as Real Madrid bounced back from two successive defeats by beating Malaga 2-1 on Saturday to go four points clear at the top of La Liga.
The Welsh, who reached the Euro 2016 semi-finals, finished runners-up on 14 points from eight games, three behind Croatia who sealed their berth on Saturday with a 3-1 win over Slovakia.
Barcelona leapfrogged Atletico Madrid to go top of La Liga after Lionel Messi's acrobatic volley secured a hard-fought 2-1 victory against tenacious Malaga on Saturday.
A round-up of Thursday night's matches from the Euro 2020 qualifiers.
Cristiano Ronaldo fired Real Madrid to a 4-1 win over Celta Vigo on Wednesday to take Zinedine Zidane's side three points clear at the top of La Liga.
Spain's Alvaro Morata scored a goal in each half as they beat a highly defensive Malta side 2-0 away on Tuesday to move top of their Euro 2020 qualifying group with two wins out of two games.
Treble-chasing Barcelona are exactly where they want to be as they prepare for two matches this week that could make or break coach Luis Enrique's first season in charge.
Arsenal slumped to a last-gasp 2-1 Premier League defeat at relegation-threatened Brighton & Hove Albion on Saturday in a blow to the London club's chances of securing European football next season. Watford's Craig Dawson grabbed a stoppage-time equaliser with an overhead kick to earn his side a 1-1 draw with Leicester City on Saturday and a vital point in their battle for Premier League survival.
United down Newcastle after Saints stun Chelsea on a dramatic night in the English Premier League.
Top-class goals from Bernardo Silva and Sergio Aguero took Manchester City back to the top of the Premier League in a 2-0 win over Fulham at Craven Cottage on Saturday.
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Real Madrid took full advantage of Barcelona's shock defeat at Real Valladolid with a 3-0 home win over 10-man Levante on Sunday that put Carlo Ancelotti's in-form side three points clear at the top of La Liga.
Sergio Ramos equalled Iker Casillas's record of 167 appearances for Spain on an emotional night at Sporting Gijon's El Molinon stadium, which paid tribute to the late Spain and Sporting forward Quini before kickoff.
Photos from the La Liga matches played on Sunday
Images from Day 3 of the Australian Open in Melbourne on Wednesday.
Manchester City claimed the win required to finally end Liverpool's relentless attempt to dethrone them as Premier League champions as they hit back from a goal down to crush Brighton and Hove Albion on the south coast on Sunday.
Gabriel Jesus came off the bench to secure Manchester City a 1-0 English Premier League victory at Leicester City after yet another penalty miss by Pep Guardiola's side on Saturday. Chelsea's Olivier Giroud and Marcos Alonso returned to the starting lineup to stunning effect by grabbing a goal apiece in a crucial 2-1 home win over Tottenham Hotspur in the battle between the London rivals for fourth place.
IMAGES from the English Premier League matches played on Saturday
England beat Nigeria 2-1 in a friendly on Saturday that provided some clues as to how coach Gareth Southgate will line up his still experimental side when the World Cup gets underway in two weeks' time.
James Maddison scored a brilliant winner to help Leicester City come from behind and beat Tottenham Hotspur 2-1 in the Premier League on Saturday in a match dominated by VAR drama.
Philippe Coutinho inspired Liverpool to a comfortable 3-1 home win over Everton in the 228th Merseyside derby on Saturday to move provisionally up to third in the Premier League.
A look at the top tweets from your favourite Bollywood celebrities.
Sergio Aguero struck twice as Manchester City came from behind to beat Burnley 2-1 at Turf Moor in the Premier League on Saturday.
News of all that's transpired on and off the football field.
An inexperienced Germany suffered an embarrassing 3-1 defeat to Slovakia in a storm-affected friendly ahead of Euro 2016.
Arsenal moved top of the Premier League table but were unconvincing in a 0-0 home draw with Middlesbrough who were well worth their point on Saturday.
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