LSG have been boosted by the return of their in-form opener Mitchell Marsh, who has slammed four fifties in five matches forming a dangerous opening partnership with Aiden Markram.
LSG's four overseas players are all batters in Markram, Marsh, Nicholas Pooran and David Miller.
CSK are taking a gamble with Shaik Rasheed opening in place of the experienced Conway.
Check out the playing XIs of the two teams:
Lucknow Super Giants: Rishabh Pant (captain, w/k), Aiden Markram, Mitchell Marsh, Nicholas Pooran, Ayush Badoni, David Miller, Abdul Samad, Shardul Thakur, Avesh Khan, Akash Deep, Digvesh Singh Rathi.
Impact Subs: Ravi Bishnoi, Prince Yadav, Shahbaz Ahmed, Matthew Breetzke, Himmat Singh.
Chennai Super Kings: Mahendra Singh Dhoni (captain, w/k), Shaik Rasheed, Rachin Ravindra, Rahul Tripathi, Vijay Shankar, Ravindra Jadeja, Jamie Overton, Anshul Kamboj, Noor Ahmad, Khaleel Ahmed, Matheesha Pathirana.
Impact Subs: Shivam Dube, Kamlesh Nagarkoti, Ramakrishna Ghosh, Sam Curran, Deepak Hooda