Wavell Hinds and Sewnarine Chattergoon will replace Shivnarine Chanderpaul and Runako Morton in the West Indies squad for the last two ODIs against India.
Chanderpaul has pulled a hamstring, however, he will remain with the team, Windies media manager said. Runako has been dropped on account of his poor show in the series.
He refused to comment on whether Chanderpaul will be fit for the Test series.
Hinds has opened with Chris Gayle in the one-dayers.
Sewnarine Chattergoon, who has played two ODIs, is a left-hand opening batsman.