Four-times champion Novak Djokovic, seeded seventh, will start against Learner Tien and could face Frances Tiafoe in the fourth round and fourth-seeded Fritz in the quarters before a blockbuster semifinal against Alcaraz.
Defending champion Jannik Sinner, who has been recovering from illness, received a more favourable route to the US Open final than Carlos Alcaraz while Aryna Sabalenka will be tested in her bid to retain her title after the draw was made on Thursday.
Top seed Sinner's health has come into focus since he withdrew from the Cincinnati final on Monday while trailing Carlos Alcaraz 5-0. He later withdrew from the since-completed mixed doubles event in New York.
Sinner, who increased his Grand Slam tally to four with wins at this year's Australian Open and Wimbledon, will open against Czech Vit Kopriva and could face fifth seed Jack Draper in the quarterfinals,
Reigning French Open champion Alcaraz, in a stacked bottom half of the draw, will begin against American Reilly Opelka and his road to the final could include a quarterfinal clash with Ben Shelton and fourth seed Taylor Fritz in the semifinal.
Four-times champion Novak Djokovic, seeded seventh, will start against Learner Tien and could face Frances Tiafoe in the fourth round and fourth-seeded Fritz in the quarters before a blockbuster semifinal against Alcaraz.
In the women's draw, top seed Sabalenka will begin against Rebeka Masarova and her fortnight could include a quarterfinal date with Cincinnati finalist Jasmine Paolini and a semifinal match with Jessica Pegula.
Wimbledon champion Iga Swiatek, fresh off winning her tune-up event in Cincinnati, could face Amanda Anisimova in the quarters.
French Open champion Coco Gauff, the third seed, could face sixth seed and fellow American Madison Keys, who won this year's Australian Open, in the quarter-finals before a possible date with Swiatek.