To make it to the main draw, Saketh needed to win three rounds in the qualifiers and he made it with minimum fuss without dropping a single set.
In the earlier rounds, Myneni, seeded 26th, won 7-6 (6), 6-4 over local lad Mitchell Krueger. Myneni beat Albano Olivetti of France 7-5, 6-3 in the first round.
The last two Indians to have qualified for a singles Grand Slam tournament proper were Yuki Bhambri and Somdev Devvarman.
Saketh, ranked 143rd in the ATP chart, lost in the third Qualifying round at the Australian Open and bowed out in the second round of the French Open earlier this year.
Pedja went into the contest 1-0 up in Head-to-Head record with a win over the Indian in Turkey in May last year but proved to be no match for Myneni on the day.
In the first set, Myneni broke Pedja thrice while the Serbian broke him once with the duration being 30 minutes.
The second set finished in only 26 minutes as Myneni broke him thrice and wrapped up the match in style.
It didn't help that Pedja had four double faults and could only hit two aces compared to Myneni's seven.
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