Play finally began after a more than two-and-a-half hour delay caused by torrential rain at the French Open on Monday.
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Three fancied players did succumb on a cheerless day.
It was a poor day for Italians in the women's draw where seventh seed Roberta Vinci was crushed 6-1, 6-3 by Ukraine's Kateryna Bondarenko and 16th seed Sara Errani, runner-up in 2012, lost to Bulgaria's Tsvetana Pironkova 6-3, 6-2.
Former US Open champion Marin Cilic, seeded 10, went down to Argentine qualifier Marco Trungelliti 7-6(4), 3-6, 6-4, 6-2.