Hamburg SV and Werder Bremen stayed on course for an all-German UEFA Cup semi-final clash with 3-1 victories over Manchester City and Udinese respectively in their quarter-final, first legs on Thursday.
Shakhtar Donetsk beat visitors Olympique Marseille 2-0 while Dynamo Kiev drew at Paris St Germain in a lacklustre goalless affair leaving open the possibility of a Ukrainian semi-final if the French clubs fail to put in improved performances.
English Premier League side Manchester City, the richest club in the world, stunned Martin Jol's Hamburg with a goal in the first minute when midfielder Stephen Ireland slotted home after a smart interchange with Brazilian Robinho.
Hamburg quickly drew level eight minutes later through Joris Mathijsen, who powered in a header from a corner, before taking the lead in the 63rd minute when Piotr Trochowksi scored from a penalty after Micah Richards handled in the box.
With 11 minutes left Trochowski, outstanding this season, provided substitute Paolo Guerrero with a low cross for the Peruvian to slam in and give Hamburg a two-goal advantage ahead of next Thursday's second leg.
Brazilian Diego scored a goal in each half to steer Werder Bremen to a 3-1 win over Udinese, the last Italian club left in European competition.
The mercurial playmaker, who has been linked by the media with a move to several top Italian clubs, scored his second goal with a curling shot from the edge of the box in the 67th minute before Hugo Almeida added a third two minutes later.
Udinese's Fabio Quagliarella pulled one back three minutes from time to give the Italians some hope.
SHAKHTAR TRIUMPH
Shakhtar Donetsk stayed on track for their first European semi-final spot with a 2-0 home win against Olympique Marseille.
Tomas Huebschman opened the scoring from close range against the run of play six minutes before the break.
The Ukrainians doubled their lead midway through the second half when midfielder Jadson finished off a Brazilian combination that included a cross from substitute Willian and a one-two between Luiz Adriano and Fernandinho.
Shakhtar defender Mykola Ischenko was booked and will be suspended for next Thursday's second leg at the Velodrome.
Paris St Germain were held to a goalless draw by Dynamo Kiev in a dull match that included few good chances.
PSG, who claimed the 1996 European Cup Winners' Cup, dominated the match but proved too clumsy in front of goal to be able to take a lead into next week's return leg in Ukraine.