AS Roma ended a five-match winless run against arch-rivals Lazio with a 2-0 win on Sunday which maintained their 100 percent record after four games in Serie A.
Federico Balzaretti and Adem Ljajic, from a penalty, scored for Roma while Lazio, last beaten by their neighbours in March 2011, had substitute Andre Dias sent off only three minutes after coming onto the pitch.
Giuseppe Rossi continued his scoring run with the second goal in Fiorentina's 2-0 win at Atalanta which left them on 10 points, level with Juventus and Inter Milan who won 7-0 at Sassuolo.
Diego Milito came on as a second-half substitute for his first appearance following a seven-month injury layoff and scored twice to help unbeaten Inter Milan rout hapless Sassuolo 7-0 away.
Inter were already leading the Serie A newcomers 4-0 when Milito, 34, came on for his first game since suffering a knee ligament damage in a Europa League match against Cluj in February.
Milito needed only nine minutes to make his mark as he turned in a cross from fellow Argentine Ricky Alvarez in the 63rd minute.
His second goal 20 minutes later was equally straightforward as he tapped in Fredy Guarin's cross from close range after Sassuolo, who have lost all four opening games in an unhappy top flight debut, were again caught on the counter-attack.
Five of the Inter goals came from Argentines with Rodrigo Palacio, Alvarez and Esteban Cambiasso also on target.
Palacio opened the flood gates in the seventh minute when he was left unmarked to tap in Yuto Nagatomo's pass after seven minutes.
Algeria forward Saphir Taider put Inter further head when he snapped up a rebound in the 23rd minute after Palacio's first effort was saved, the 21-year-old's first goal since his move from Bologna in the close season.
Sassuolo's nightmare continued when Raffaele Pucino, making his Serie A debut after replacing the injured Marcello Gazzola after 14 minutes, headed Guarin's cross into his own net just after the half hour.
Alvarez added the fourth in the 53rd minute while Cambiasso scored the best goal of the game when he curled in a 20-metre effort, sandwiched between Milito's goals.
Inter, unbeaten under new coach Walter Mazzarri, have taken 10 points from their opening four games.
Image: AS Roma players celebrate the team's second goal scored by Adem Ljaijc during the Serie A match against SS Lazio at Stadio Olimpico in Rome on Sunday
Photograph: Paolo Bruno/Getty Images
Serie A: Totti, Strootman help Roma maintain perfect start
10 Movies Where Love Was BLIND
World Cup qualifier: Injured Messi in Argentina squad
Mourinho urges out of favour Mata to prove him wrong
Mata must adapt to what Chelsea want, says Mourinho