It was the third straight and sixth U.S. Open crown for the 32-year-old American, her 18 career slams putting her into a tie with Chris Evert and Martina Navratilova for fourth place on the all-time list.
Having failed to get beyond the last 16 of the year's first three slams, Williams sailed through the U.S. Open without dropping a set, finishing off Wozniacki in a snappy 75 minutes.
For the 10th seeded Wozniacki, back in a Grand Slam final for the first time in five years, it was another frustrating end to a promising fortnight as she once again left Flushing Meadows empty handed, a major title still beyond her grasp.
Image: Serena Williams celebrates with the trophy after defeating Caroline Wozniacki to win their women's singles final match of the 2014 US Open
Photograph: Streeter Lecka/Getty Images