The top seeds lost to the fourth seeded French-Slovak combine of Caroline Garcia and Katarina Srebotnik 5-7, 4-6 in 81 minutes.
The Indo-Swiss pair split US $11,360 in prize-money and collected 185 ranking points each from the grass-court tournament, the last before the Wimbledon Championships.
Sania-Hingis had 15 break chances but converted only three while Caroline-Katarina effected five breaks from the 12 they forced.
Image: Sania Mirza (left) and Martina Hingis in action at the Aegon International in Eastbourne.
Photograph: Ben Hoskins/Getty Images for LTA
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