Former 100 metres World record holder Asafa Powell has been forced to withdraw from his first meeting since last year's Olympic final because of a hamstring injury, Athletics Australia said on Tuesday.
The 30-year-old Jamaican, who has run the 100m in less than 10 seconds more times than any other sprinter, was scheduled to race at the IAAF World Challenge in Melbourne on Saturday.
Powell suffered a groin injury in the Olympic final in London last year and trailed home last as his compatriots Usain Bolt and Yohan Blake won gold and silver.
Britain's Olympic long jump champion Greg Rutherford will renew his rivalry with Australian silver medallist Mitch Watt at Saturday's meeting at Lakeside Stadium.
Blake to run at opening Doha Diamond League meeting
Australia names Briton Nathan new athletics chief
Ex-PM says Australia's sports image 'torpedoed' by doping report
Olympic champion Bolt beaten in season opener
Australia report says drug use in sports 'widespread'