PHOTOS: Kyrgios stuns Djokovic again, Federer thrashes Nadal

IMAGE: Nick Kyrgios reacts during his match against Novak Djokovic. Photograph: Clive Brunskill/Getty Images

Nick Kyrgios ended Novak Djokovic's 19-match winning run at Indian Wells by beating the Serb 6-4, 7-6(3) to reach the BNP Paribas Open quarter-finals in Indian Wells on Wednesday, while Roger Federer also advanced with a straight sets win over Rafael Nadal.

Australian Kyrgios had beaten Djokovic in the quarter-finals in Acapulco almost two weeks ago in their first career meeting, and repeated the feat on Wednesday to reach the last eight, where he will face Federer.

IMAGE: Novak Djokovic in action. Photograph: Clive Brunskill/Getty Images

The Swiss defeated Nadal 6-2, 6-3 in the 36th

meeting between the pair.

Federer, who got the better of his Spanish rival in a thrilling five-setter at the Australian Open final in January, broke Nadal’s serve to open the match then survived a break point to hold with a backhand winner down the line for 2-0.

IMAGE: Roger Federer in action. Photograph: Jayne Kamin-Oncea-USA TODAY Sports/Reuters

The Swiss then took a 4-1 lead before sealing the set and continued to press in the second, keeping Nadal on his heels.

In other matches, Japan’s Kei Nishikori beat Donald Young 6-2 6-4 and advances to play 17th-seed Jack Sock, who defeated Malek Jaziri in three sets, while Uruguay’s Pablo Cuevas upset 11th-seed David Goffin 6-3 3-6 6-3.