"M_Granollers & @Leander withdraw from #ACO2016 Doubles as the Spaniard is suffering from an illness," tweeted the official handle of the Aircel Chennai Open.
The second seeds were to face Austian Krajicek and Benot Paire in the quarter-finals on Thursday.
"It is a huge disappointment for me that I won't be able to play in front of my home crowd. I hope Marcel gets fit in time for the Australian Open," said Paes.
Paes and Granollers had beaten Taro Daniel and John Millman in the opening round on Tuesday.
Image: Leander Paes