The Spaniard arrived in London needing a minimum of two victories at the year-ending showpiece and, after breezing past David Ferrer on Tuesday, he was stretched to the limit by Swiss Wawrinka in his second round-robin match before coming through 7-6(5), 7-6(6).
His straight-sets victory means 13-times Grand Slam champion Nadal is assured of a semi-final spot at the event which he has never won, while tournament debutant Wawrinka can also still make the last four if he beats Ferrer on Friday.
Nadal served for the first set at 5-4 but Wawrinka broke with some dazzling attacking play and then went toe to toe with the top seed in the tiebreak before an unfortunate stumble as he approached the net at 5-6 down allowed Nadal to crunch a forehand winner away and pocket the opener.
Wawrinka delighted the crowd as he battled back from 4-1 down in the second set and seemed poised to take it to a decider when he held a set point in another tense tiebreak only to succumb to Nadal for the 12th time in their 12 meetings, during which he has never won a set.
Image: Rafa Nadal
Photograph: Clive Brunskill/Getty Images
Djokovic douses Federer's fire, Nadal crushes Ferrer
World Tour Finals: Wawrinka, Del Potro give taste of things to come
Djokovic, Nadal suggest ATP rotate Finals venue
ATP World Tour Finals: No respite for Federer as Djokovic clash looms
World Tour Finals: Nadal drawn with Ferrer, Djokovic with Federer