Barcelona coach Luis Enrique has decided to rest Lionel
Barca have a 5-0 lead from last week's first leg at the Nou Camp and Luis Enrique has called up six players from the B team, including teenage Croatia midfielder Alen Halilovic for the return game.
Playmaker Xavi and defender Thomas Vermaelen will miss the match due to injury, while centre back Gerard Pique and midfielder Ivan Rakitic are the only players included who featured in Sunday's 3-1 La Liga win at home to Atletico Madrid, Barca said on their website (www.fcbarcelona.es).
Barca are likely to face Atletico in the quarter-finals as the La Liga champions take a 2-0 advantage over holders Real Madrid into their last 16, second leg at Real's Bernabeu stadium later on Thursday.
Sevilla, Athletic Bilbao, Villarreal, Malaga, Espanyol and Getafe are already through to the last eight.
Image: Neymar, left, and Lionel Messi look on during a FC Barcelona training session
Photograph: Alex Caparros/Getty Images
'Messi will remain at Barca for years to come'
Barca's Busquets insists all is well between Messi and coach Enrique
How football managers react when they are sent off...
Is Cristiano Ronaldo single again?
Ronaldo says his son is a Messi fan