Lionel Messi helped Barcelona triumph at a venue where champions Real Madrid lost two weeks ago, scoring twice at Granada in La Liga on Saturday to pass 300 goals for the club and earn the leaders a 2-1 win.
A revitalised Granada, under new coach Lucas Alcaraz, beat Real 1-0 after Cristiano Ronaldo headed an own goal at Los Carmenes as Jose Mourinho's men were undone by hard-running and abrasive hosts.
Odion Ighalo handed Alcaraz's team a 26th-minute lead on Saturday but World Player of the Year Messi came to Barca's rescue by taking his tally of goals to 301 in 366 matches for the Catalan side.
The 25-year-old product of Barca's famed youth academy took his league total this season to an unmatched 37 goals and made it a record 14 consecutive league matches in which he has scored.
"It's great for him and for us that he continues to score goals," Barca full back Jordi Alba told Spanish television.
"Today we found it very difficult but in the end it was Lionel who decided the game. You can't speak highly enough about Messi."
The win put Barca 15 points clear of second-placed Atletico Madrid and 19 ahead of Real who are third.
Atletico visit Real Valladolid on Sunday when Real host city rivals Rayo Vallecano.
Messi joined Barca as a 13-year-old in 2000. He was given his senior debut by then-coach Frank Rijkaard four years later and has gone on to become the club's leading all-time scorer.
He has 206 goals in La Liga and 56 in the Champions League where he has been the leading scorer for the last four seasons.
Messi has also notched 24 goals in the King's Cup, 10 in the Spanish Super Cup, one in the European Super Cup and four in the Club World Cup.
Photograph: David Ramos/Getty Images