Manchester United forward Robin van Persie is unlikely to be fit for the Premier League derby match against Manchester City later this month, manager Louis van Gaal said on Friday.
The 31-year-old has missed the last five games with an ankle problem suffered in the 2-1 defeat at Swansea City on February 21.
The Dutchman has already been ruled out of this Saturday's league game at home to Aston Villa and asked if he would be fit to face City on April 12, Van Gaal said: "I don't think so.
"The process has to give me signals he is ready for that but I know that from my experience it is not like that."
Van Gaal earlier told MUTV that Van Persie was recovering along with left back Luke Shaw, who has been out with a hamstring injury.
"Robin is coming back on the (training) pitch and Luke Shaw has already had a week on there but match rhythm is very important," said Van Gaal.
"You cannot compare a player who has been out for four or five weeks to those that have sufficient match rhythm."
Van Gaal explained later in his news conference: "We have a process for injured players in the medical department, they then go to a football coach for tests and then to me.
"Robin still isn't with the football coach. He's still not in my group. Luke Shaw is in my group, that's different, but Van Persie isn't available."
United are fourth in the standings with 59 points from 30 games, a point behind Arsenal and two adrift of City. Chelsea, who United visit on April 18, are top with 67 points.
Hummels denies making promise to United's Van Gaal
Everything you want to know about EPL championship race is here!
'Unlucky United forgot to score against Swansea'
EPL PHOTOS: Kane nets first league hat-trick; City, Arsenal win
EPL: Something has to give when Liverpool host United