EPL PHOTOS: Slick Liverpool sink Manchester United

Two second-half goals from substitute Xherdan Shaqiri gave Liverpool a 3-1 Premier League win over Manchester United at Anfield on Sunday as Juergen Klopp's side regained top spot with a pulsating performance in the North West derby.

Unbeaten Liverpool have 45 points from 17 games with champions Manchester City, who beat Everton 3-1 on Saturday, a point behind.

United are 19 points adrift of Liverpool in sixth place -- the biggest gap between the clubs at this stage of this season for 46 years -- and a daunting 11 points behind the top four.

Jose Mourinho's side's 26 points is their lowest return after 17 games in the Premier League era and the defeat, which could have been even more emphatic, is sure to re-open questions about the manager's future.

Mourinho left French World Cup-winning midfielder Paul Pogba on the bench as he opted for a defence-orientated line-up but his attempt to get a third straight draw at Anfield ended in failure.

Klopp's side were faster, smarter and more incisive than a United team again lacking cutting edge and looking mediocre against opponents who look equipped to fight ManchesterCity all the way for the title, even if their manager insisted the summit duel was far from his mind.

"Today we played United. For one second we didn't think about (City). We wanted to win the game which was difficult enough," Klopp told reporters.

"We know we are a good football team. We had to prove it and keep on proving it. I'm over the moon about the performance. The way the boys played tonight was outstanding," the German added.

Klopp's side roared out of the traps and took the game to United, grabbing the lead in the 24th minute when Sadio Mane chested down a pass from Fabinho and slotted past David De Gea.

Against the run of play, United drew level in the 33rd minute when Liverpool keeper Alisson Becker spilled a harmless low cross from Romelu Lukaku and Jesse Lingard pounced on the loose ball to find the net.

The hosts continued to dominate but too often were restricted to long-range efforts and it was not until the introduction of Swiss international Shaqiri that the game turned decisively in their favour.

Mane's pull back from the byline took two deflections as it ricocheted to Shaqiri on the edge of the area and his shot flew off Ashley Young and into the top corner to make it 2-1 in the 73rd minute.

Seven minutes later fortune was on Shaqiri's side again as another deflected shot, this time off Eric Bailly, beat the helpless De Gea.

The Swiss, who has impressed from the bench and in his starts for Liverpool, said he used his disappointment at being left among the subs to fire himself up.

"Every player is not happy when he is on the bench, that’s pretty normal. But only 11 players can play – the coach decides,” he said.

“I always try to make an impact when I come on or play from the beginning. Today was a very good impact with the two goals, I’m delighted."

As the now ritual condemnation of his team from former United players began on television, Mourinho was quick to defend his players.

"The players gave everything and when they give everything I'm never upset with them, I have a good feeling towards them," he said while accepting they had struggled to cope with Liverpool's dynamism.

"The players gave what they gave, there was a difference of intensity and physicality, pressing and transitions. They were fast and aggressive, we had difficulties to cope," he said.