World number seven Juan Martin del Potro has withdrawn from next week's Madrid Open because of a viral infection, organisers said on Friday.
The heavy-hitting Argentine reached the semi-finals last year before losing to Czech Tomas Berdych.
Belgian David Goffin, who was in the qualifying tournament, will take Del Potro's place in the main draw.
The claycourt Masters Series tournament features the big four of world number one Novak Djokovic, defending champion Roger Federer, Andy Murray and Rafael Nadal.
Photograph: Clive Brunskill/Getty Images
Barcelona Open: Ferrer shocked, Nadal eases through
Djokovic battles through pain, Nadal finds it easy
Injured Djokovic to play in Monte Carlo
'To get up, you have to fail once in a while'
Nadal routs Raonic to close on eighth Barcelona title