Rafael Nadal and Roger Federer, numbers two and three in the world, suffered surprise defeats to inspired opponents in an entertaining quarter-finals day at the Cincinnati Open on Friday.
To the delight of a packed home crowd, American hard court specialist Mardy Fish beat Nadal for the first time in his career, 6-3, 6-4, to book a spot in the semi-finals, where he will face Britain's Andy Murray.
Then Federer was undone 6-2, 7-6 (3) by Czech Tomas Berdych, who after beating him twice last year is becoming something of a bogeyman for the Swiss.
Berdych will face world number one Novak Djokovic, who survived an early scare against France's Gael Monfils before recovering to win 3-6, 6-4, 6-3 and extending his season record to 56-1.
Nadal handed Fish the advantage in the first set with a double-fault on break point, and the American played on with greater confidence.
The seventh-seeded Fish, who produced 12 aces, made the decisive break to go up 3-2 in the second set when Nadal went long on a return.
After having the bandage on his foot changed, Nadal found some extra power as he fought in vain to break back.
But Fish's powerful serve was on display in the final game when he served to love for the match.
Nadal, who burnt his fingers on a hot plate at a local restaurant earlier in the week, had played a three and half hour, three-setter against Fernando Verdasco on Thursday and then kept his doubles commitment.
But he said his game had simply not been at its best.
"I didn't play well. It was a bit of an unlucky week for me with the burned fingers and the very long match yesterday. There is no excuse though -- the only excuse is that he played better than me," he said.
Fish, who lost to Nadal at Wimbledon, said this match had felt different from the outset.
"There is that difference between the feeling that you can win or even that you should win rather than that you hope to win," he said.
The center court crowd then watched another surprise as Berdych delivered a reminder of his quality.
Federer, who had won 24 of his previous 26 games in Cincinnati, never got to grips with Berdych's powerful serve as he suffered another setback following a third-round exit in Montreal last week.
The only negative for Berdych was a shoulder injury which he hoped would clear up in time to face Murray.
"I hope I will be OK. I will try to do my best with my team to get the shoulder back ready and be 100 percent for the match," he said.
Murray enjoyed a comfortable 6-3 6-3 win over France's Gilles Simon in his quarter-final.
The Scot, who has won the last seven meetings with 10th seed Simon, exchanged breaks with his opponent to start the match but was in control the rest of the way, showing the patience needed to deal with the Frenchman's preference for long rallies.
Simon was the only player outside the top eight seeds to reach the quarter-finals after a three-set win over Spain's David Ferrer on Thursday that lasted over three hours.