Barcelona, AC Milan and Arsenal can all book places in the knockout stages of the Champions League with wins on Tuesday.
Holders Barcelona travel to Prague to play Viktoria Plzen and Serie A champions Milan visit Belarussian side BATE Borisov in Group H while Arsenal host Olympique Marseille in Group F.
Chelsea, who can also go through if Valencia fail to beat Bayer Leverkusen at home, will hope for a repeat of their result two weeks ago when they beat the Belgian club 5-0 at Stamford Bridge.
Surprise package APOEL Nicosia can strengthen their position at the top of Group G with victory over Europa League champions Porto, who have had only one win in their opening three encounters.