The world No.1 duo broke the 11th seeds once in each set to claim their fifth US Open title and take their 16th Grand Slam title together.
The top seeds made their move in the fourth game of the opener and when they broke in the seventh game of the second set there was no way back for the Spanish pair.
Left-handed Bob Bryan served out for an historic victory.
The win gave the 36-year-old brothers a first Grand Slam title of the year and they have now won at least one grand slam title together for 10 consecutive years.
Image: Bob and Mike Bryan celebrate after winning the US Open doubles title
Photograh: Matthew Stockman/Getty Images