World number seven Tomas Berdych has withdrawn from the Barcelona Open due to illness, organisers said on Tuesday.
The Czech fifth seed has gastroenteritis and will be replaced in the draw by Rui Machado of Portugal, according to the tournament website (www.barcelonaopenbancsabadell.com).
Britain's Andy Murray, who lost to Nadal in the semi-finals in Monaco and is seeded second in the Catalan capital, is struggling with an elbow injury.
An ATP spokesman said he would train on Tuesday before making a decision on whether he can compete.