Defending champion Novak Djokovic was knocked out of the Australian Open quarter-finals by Stanislas Wawrinka 2-6, 6-4, 6-2, 3-6, 9-7 on Tuesday.
Djokovic and Wawrinka were involved in a tense five-setter last year but the Serb had scraped through in that.
However, the much-improved Swiss got the better of the four-time winner on this occasion.
Earlier, Berdych fended off a belated challenge from baseline hustler David Ferrer to reach his maiden Australian Open semi-final on Tuesday with a gritty 6-1, 6-4, 2-6, 6-4 victory.
The rangy seventh seed cruised to a two-set lead over a surprisingly listless Ferrer but spontaneously collapsed in the third set under pressure from the dogged Spaniard.
Ferrer appeared primed to drag the match into an epic struggle but lost focus at 2-2 in the fourth set to surrender serve with a string of unforced errors.
Image: Stanislas Wawrinka of Switzerland celebrates a point against Novak Djokovic of Serbia during the Australian Open at Melbourne Park.
Photo: Michael Dodge/Getty Images
Australian Open PHOTOS: Cool teen Bouchard beats Ivanovic to reach semis
Australian Open PHOTOS: Ivanovic upsets Serena; Djokovic Ferrer march into quarters
PHOTOS: Federer leads 'Big Four' charge into quarters
Australian Open: Nadal survives Nishikori scare; Sharapova exits
Five teams unveiled for Bhupathi's inaugural tennis league