"I'm very satisfied with the Ajax job," he told reporters at a media conference. "I'd only leave once there is no more challenge here."
Speculation has continued to place the former Dutch international on the list of candidates for the Spurs job after last weekend's departure of Andre Villas-Boas.
He had one day earlier said he would have been "honoured" by the interest from the Premier League club. "It means I have good standing. But I am staying at Ajax," he said after Thursday's 3-0 club win over amateurs Ijsselmeervogels.
"Spurs are not a club I'm interested in moving to at the moment. But I think they are certainly a great club. Just as it was with Liverpool, it is to do with the timing. But I'm not finished at Ajax."
De Boer is chasing a record fourth successive Dutch league title and this season's Europa League title.
Last year the 43-year-old, who played at Ajax, Barcelona, Galatasaray and Scottish club Rangers, had a discussion with Liverpool about the manager's job at Anfield. He has since signed a contract until 2017 with Ajax.
Image:AjaxAmsterdam head coach Frank de Boer
Photographs: Anoek de Groot/EuroFootball/Getty Images
The Top 10 Sporting Breakthroughs in 2013
Sindhu the new star as Saina endures title drought
Deepika Kumari and co keep Indian archery on target in 2013
2013 belonged to Nadal, Serena while Murray ended British wait
EPL sack race: The five to fall this season