In his autobiography "Open", the American candidly describes being introduced to the drug in 1997 and the moment when he was informed he had failed a drugs test.
International Tennis Federation (ITF) president Francesco Ricci Bitti said he was "surprised and disappointed" by the revelations and World Anti-Doping Agency (WADA) chief John Fahey called on the ATP to "shed light" on the circumstances that allowed Agassi to escape punishment.
In his book, Agassi, now 39, spoke of the moment he took crystal meths, a highly-addictive amphetamine, for the first time when his career was in freefall. He was helped by his drug-user assistant, known as Slim.
"Slim dumps a small pile of powder on the coffee table. He cuts it, snorts it. He cuts it again. I snort some. I ease back on the couch and consider the Rubicon I've crossed," he said.
"There is a moment of regret, followed by vast sadness. Then comes a tidal wave of euphoria that sweeps away every negative thought in my head. I've never felt so alive, so hopeful -- and I've never felt such energy."
Agassi, now married to former women's number one Steffi Graf with whom he has two children, ended 1999 atop the rankings after winning the US Open again. He retired in 2006.
However, had tennis's doping programme been under the WADA code at the time there is little doubt his cover-up of his drug taking would have failed and his career could have been ruined.
Agassi, in extracts from his book serialised in the Times, remembers receiving a phone call in 1997 from a doctor working for the ATP who informed him that he had failed a drugs test.
"My name, my career, everything is now on the line. Whatever I've achieved, whatever I've worked for, might soon mean nothing. Days later I sit with a legal pad in my lap and write a letter to the ATP. It's filled with lies interwoven with bits of truth," Agassi said.
AGASSI ASHAMED
He said the ATP threw out the case against him after he concocted a story that he had accidentally drunk a soda spiked with crystal meth belonging to Slim.
Agassi's admission that he took drugs casts a shadow over a player widely regarded as one of the greatest ever while it also exposes the ATP's lack of strict doping controls at the time.
"This is a very serious statement which, if reported accurately, is one that is disappointing coming from a role model such as Andre Agassi," Fahey said.
The ITF has been responsible for the ATP Tour's anti-doping programme since 2006 and the women's WTA Tour a year later.
"The ITF is surprised and disappointed by the remarks made by Andre Agassi in his biography admitting substance abuse in 1997," Ricci Bitti said in a statement.
"The events in question occurred before the World Anti-Doping Agency (WADA) was founded in 1999 and during the formative years of anti-doping in tennis when the programme was managed by individual governing bodies."
"The ITF, Grand Slams, ATP and WTA Tour are now unified in their efforts to keep tennis free of drugs. This should not be overshadowed by an incident that took place over 12 years ago."
Agassi said he was not worried about the impact of his revelations. "I was worried for a moment, but not for long," he told People magazine's website.
"I wore my heart on my sleeve and my emotions were always written on my face. I was actually excited about telling the world the whole story."
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