Serbian Djokovic, the defending French Open champion, announced on Sunday that he would have eight-times grand slam champion Agassi in his corner in Paris after parting ways with his coaching team earlier this month.
"It's brand new and good for tennis," Leconte, the last Frenchman to reach the final in 1988, said.
"I really hope it works because if it does, it could be something special for Novak."
Twelve-time Grand Slam winner Djokovic ended a three-year partnership with Boris Becker late last year when he lost his world number one status to Andy Murray.
He has struggled to rediscover his best form since winning last year's French Open to complete a career grand slam and this season has seen a run of surprise losses.
Leconte says American Agassi, who came back from a career slump to win the 1999 French Open, could help the 30-year-old find the spark that appears to have been missing.
"I really believe that he can help Novak find his way back to the top," Leconte, who will work as a pundit for Eurosport during the French Open, said.
"Andre has the strength of personality to give Novak advice. He had the experience of coming back after injury problems and other setbacks to come back from 150 in the world to number one.
"It's not about coaching. I think the likes of Novak, Roger (Federer) and Rafael (Nadal) just need something new. A brand new direction. I really hope Novak has enough strength and power to produce what he produced last year."
Image: Andre Agassi, left, with Novak Djokovic.
Photograph: Daniel Munoz/Reuters
No, no never! That's what Sakshi said about Bollywood
When Manchester City and United came together
ICC to review security for Champions Trophy after Manchester attack
Sports shorts: Chelsea's Conte named Manager of the Year
All you want to know about IPL 10