Manchester United will be at home to Arsenal in the stand-out tie of the fifth round of the FA Cup following Monday's draw.
United are seeking to extend their record number of FA Cup wins to 12 while Arsenal, the second-most successful club in the competition's history, need one more success to match United's current tally.
Holders Chelsea will expect to advance after being given a home draw against League One (third division) Huddersfield Town, as will Liverpool, at home to Championship (second division) Barnsley.
Bristol Rovers of League One have a good chance to reach the sixth round, having been drawn at home to Championship side Southampton.
The matches will be played over the weekend of 16-17 Feb with the final at Wembley on May 17.
Full draw
Bristol Rovers (III) v Southampton (II)
Cardiff City (II) v Wolverhampton Wanderers (II)
Sheffield United (II) v Middlesbrough
Liverpool v Barnsley (II)
Manchester United v Arsenal
Preston North End (II) v Portsmouth
Coventry City (II) v West Bromwich Albion (II)
Chelsea v Huddersfield Town (III)