Manchester United face Arsenal in the match of the round at Old Trafford. United forward Louis Saha is still out with a cartilage problem but Wayne Rooney returns after being suspended for last week's derby against Manchester City.
Arsenal, five points clear of United at the top of the Premier League table, are likely to be without Thomas Rosicky (hamstring) for their fourth FA Cup meeting with United in the last six seasons. Midfielder Abou Diaby is out with a calf strain.
Holders Chelsea face League One (third division) Huddersfield Town for the second time in the FA Cup in three seasons. They have almost a full squad to chose from after the return of their players from the African Nations Cup and the return to fitness of Frank Lampard, John Terry and Andriy Shevchenko.