Sevilla claimed their place in the knockout stage of the Champions League and went top of Group H when they ended Arsenal's unbeaten run this season with a 3-1 comeback win on Tuesday.
Already qualified Arsenal took an early lead in a pulsating match at the Sanchez Pizjuan when Croatia striker Eduardo da Silva steered a close-range shot past keeper Andres Palop from a tight angle after a neatly-worked move down the right.
But Sevilla hit back with a thundering strike from midfielder Seydou Keita midway through the half and a clever glancing header from leading scorer Luis Fabiano 11 minutes before the break.
Former Tottenham Hotspur striker Frederic Kanoute wrapped up a memorable win with a penalty two minutes from time after he had been bundled over in the area.
The win left Sevilla top on 12 points, two clear of Arsenal with one game left to play. The Andalucians visit Slavia Prague in their final match, while Arsenal are at home to Steaua Bucharest.