Among a host of mouthwatering clashes, Czech Republic face neighbours Germany in a top-of-the-table Group D tie in Prague. Both have 10 points from four matches.
England look to revive their faltering campaign with a much-needed victory in Israel on Saturday. Steve McClaren's men have dropped to third in Group E, a point behind Russia and three behind leaders Croatia who host Macedonia in Zagreb.
Spain, who languish in fifth place in Group F, nine points behind leaders Sweden, also cannot afford to slip up when they host Denmark at the Bernabeu.
Passion is sure to run high in Athens where champions Greece host Turkey. Joint Group C leaders on nine points, both have yet to concede a goal.
Scotland caused a major upset by beating France 1-0 in October and Alex McLeish's Group B leaders will aim to consolidate at home to Georgia.
World Cup runners-up France visit Lithuania missing a host of key players.
Coach Raymond Domenech is forced to experiment in the absence of captain Patrick Vieira and forwards Thierry Henry, Franck Ribery and Louis Saha.