Leander Paes and Nenad Zimonjic, seeded sixth, lost to third seeded Mike and Bob Bryan in the men's doubles quarter finals at the French Open on Wednesday.
Paes and Zimonjic were beaten 6-7 (5-7), 3-6 by the American pair.
Earlier, seventh seeds Mahesh Bhupathi and Lisa Raymond bowled out of the mixed doubles.
The Indo-US pair were shown the door by fourth seeds Anastasia Myskina of Russia and Jonas Bjorkman of Sweden, losing 4-6, 2-6 in the quarter-finals.
Sixth seeds Leander Paes of India and Martina Navratilova of the United States take on the United States' Corina Morariu and Jared Palmer in another quarter-final later in the day.