Prime Minister Manmohan Singh and US President George W Bush will discuss bilateral and international issues, including the fight against terrorism, when they meet in New York on Tuesday.
At their breakfast meeting a few hours ahead of the United Nations General Assembly session, the leaders of the world's two major democracies will consider ways to deepen the "strategic partnership", which has taken a major step forward with the US easing restrictions on the supply of equipment and technology for India's space and nuclear programmes.
Closely watched will be Singh's first meeting with Pakistan President Pervez Musharraf on Friday where confidence-building measures, including steps to increase people to people contacts, will be discussed.
Prior to leaving New Delhi, Singh said he expected the meeting with Musharraf to be "wholesome" and a "further step" in the ongoing bilateral dialogue between the two countries.
All issues, "very much including Kashmir", will be on the table when the two leaders meet.
New Delhi is concerned at Pakistan's failure to dismantle terrorist infrastructure.
This issue could come up during Singh's discussions with the world leaders as he presses for sustained and united fight against terrorism.