A medical transport jet with a child patient and five others aboard crashed in a neighbourhood of Philadelphia and set multiple homes on fire on Friday.
Videos on social media showed vehicles on fire and a large emergency response from authorities.
According to US media reports, all six people aboard were from Mexico.
The child had been treated in Philadelphia for a life-threatening condition and was being transported home to Mexico, according to Shai Gold, Jet Rescue Air Ambulance spokesperson.
The flight's final destination was Tijuana after a stop in Missouri.
According to the Federal Aviation Administration (FAA), the crash occurred on Friday evening near Roosevelt Mall.
United States President Donald Trump said that “more innocent souls were lost” in the “sad” Philadelphia plane crash.
“More innocent souls lost,” Trump said on his social media platform Truth Social. “Our people are totally engaged.”
The crash came just two days after the deadly mid-air collision involving a passenger plane and a US Army Black Hawk helicopter near Washington, DC airport, killing 67 people.