Ibuprofen and diclofenac belong to a family of drugs known as 'non steroidal anti-inflammatories' (NSAIDs).
The study, undertaken by British and Italian researchers, indicated that high doses of ibuprofen and diclofenac could lead to a heart attack. Some time ago, new generation drugs like Vioxx, called COX 2 inhibitors -- were banned following similar linkages.
The researchers analysed data from 138 trials among 140,000 people, and concluded that for every 1,000 people taking either an NSAID or COX 2 inhibitor, about three extra people a year would have a heart attack.
"This meta analysis has shown that selective COX 2 inhibitors are associated with a moderate increase in the risk of vascular events, as are high dose regimens of ibuprofen and diclofenac, but that high dose naproxen (another NSAID)
'However, the average increased risk of vascular events was modest among the people studied in the trials: For every 1,000 people taking an NSAID or COX 2 inhibitor, around three extra people per year would have a vascular event, most likely a heart attack,' the report said.
'The authors conclude that very large randomised trials are needed to identify which anti-inflammatory drug regimens minimise serious cardiovascular and gastrointestinal problems,' the Journal said.
An accompanying editorial discusses other options for treating chronic pain and suggests that doctors work with their patients to choose the best solutions for them.