"Other countries can not stop Iran's uranium enrichment program," Kharazi was quoted as saying after a cabinet meeting on Wednesday.
Talks were on with Britain, Germany and France to remove European apprehensions about Iran's nuclear programme, and Iran would evaluate the negotiations in mid-March. The talks would go on only if the result of the evaluation was positive, he said.
Reiterating that the Islamic Republic had no intention to produce nuclear weapons, the foreign minister criticized the US, saying all its plans in the Middle East were aimed at helping Israel.
"Washington is trying to make up
Abandon hostile policy, Iran tells US
Iran suspended its uranium enrichment activities in November following EU incentives, but subsequently the two sides differed over key issues such as Iran's building of a nuclear reactor.
Iran rejected the EU proposal to abandon plans to build a heavy-water reactor in exchange for a light-water research reactor provided by Europe.
Washington, accusing Iran of developing nuclear weapons secretly, has warned of preemptive strikes.