He was in his late 60s.
He is survived by wife, a daughter and a son.
Ramakrishna, who sang about 5,000 songs in a career spanning nearly four decades, had huge hit songs to his credit in films like Andala Ramudu, Alluri Sitarama Raju and Mutyala Muggu.
His songs in N T Rama Rao's Pothuluri Veerabrahmendra Swamy Charitra were a runaway success.
He was also popular for a number of devotional songs that he sang.
Ramakrishna's son Sai Kiran is a popular film and television actor.
Several film personalities, including singer S P Sailaja, Sunita and music directors like R P Patnaik, paid homage to the departed soul.
Photograph: Kind courtesy V Ramakrishna page/Facebook
'TRS men lured us to change loyalties,' allege 2 TDP MLAs
Cash-for-vote: TDP MLA home raided, flurry of cases against KCR
Political big-wigs, tinsel town grace Telugu actor Allari Naresh's wedding
Baahubali audio launch postponed