Sapna, 41, who is known for her tattoos, has appeared in the advertisement which asks people to be comfortable in their own skin and not to use fur and leather items.
Her photograph in the advertisement comes with the slogan 'Ink, not mink'.
"After I educated myself and saw a few films on the cruelty and what happens to animals, I realised that it just wasn't worth it. I take a very strong stance on leather. Pleather is a great substitute for leather. And if you don't know what it is, I just say go to your local shop and ask for that substitute because it is available," Sapna said in a statement.
This is not the first time that Sapna has put her weight behind PETA.
She appeared two years ago in another PETA ad holding a pair of scissors and posing next to the caption, 'Cut Hair, Not Frogs. Choose to Refuse to Dissect Animals'.
Bigg Boss's Urvashi: I've never earned so much money
Bigg Boss's Sapna: Salman is a male chauvinist
Imam: I misbehaved with Salman in Bigg Boss
IMAGES: The hottest celebrity vegetarians of 2012!
The BEST Television shows of 2012