The event that took place at the Greek Theatre in Los Angeles recognised performances in the genre of sci-fi, horror, fantasy and comic-inspired films and TV shows.
Fox landed with the prize for her role in Transformers: Revenge of the Fallen, the Daily Star reports.
The movie also received an award for special effects, apart from Isabel Lucas winning the breakout performance trophy for her role as a seductive, shape-shifting robot.
Also, vampire movie Twilight scooped four awards including best fantasy film, breakout performance for Taylor Lautner and best fantasy actors for stars Robert Pattinson and Kristen Stewart.
Hollywood stars Tobey Maguire, Jessica Alba, Kate Bosworth, Harrison Ford, Justin Long and Christina Ricci were present at the event to hand out the awards.
Photograph: Fred Prouser/Reuters