According to a New York Magazine Vulture report, Zuckerberg plays the entrepreneurial role model for Lisa Simpson in the episode titled ''Loan-A Lisa.''
Zuckerberg's voice performance has already been taped.
'I'm not sure which episode it is, but I think I'm going to be in some episode of The Simpsons,' the Age quoted Zuckerberg as telling Mashable.com.
The Simpsons is known for the quality of the celebrity guest stars, who often play themselves.
Everyone from Golden Girls' Betty White and entrepreneur Mark Cuban to cyclist Lance Armstrong and American fooball stars the Manning brothers have taken to The Simpsons to voice their own likenesses.
Photograph: Sebastien Nogier/Reuters