Markets have started the session on a lower tracking weakness among global peers.
Further, the derivatives expiry for the month of November and the commencement of winter session of the Parliament will keep the traders on the edge.
The Sensex has opened lower by 100 points at 25,715 and the Nifty slipped 30 points at 7,819.
Asian shares dragged their feet on Tuesday after a healthcare mega-merger failed to impress investors while the dollar held firm near an eight-month high as investors grew more convinced of a US rate hike next month.
MSCI's broadest index of Asia-Pacific shares outside Japan was almost flat while Japan's Nikkei dipped 0.1% after a long weekend.
Wall Street shares edged down on Monday with Pfizer's plan to buy Allergan in a $160 billion deal quickly drawing criticism from politicians as a tax dodge.