The 30-share Sensex ended down 91 points at 18,793 and the 50-share Nifty ended down 36 points at 5,659.
Asian shares ended mixed and the dollar steadied, as a pick-up in Chinese factory activity and a commitment by the U.S. Federal Reserve to its aggressive stimulus stance soothed sentiment.
Nikkei gained 1.3% , Shanghai Composite rose 0.3% and Straits Times ended 0.6% up.
However, Straits Times ended lower.
The HSBC Purchasing Managers' Index for China revived to 51.7 in March from 50.4 in February, pointing towards solid but not spectacular first-quarter growth in the world's second-largest economy.
European stocks were trading lower and the euro dipped on Thursday because of concerns over Cyprus but a pick-up in Chinese factory activity and the U.S. Federal Reserve's commitment to its loose policy stance limited the losses.
Back home, on the political front, President Pranab Mukherjee today accepted the resignation of five Ministers belonging to DMK, which withdrew support to the UPA government on the Sri Lankan Tamils issue.
Realty Index was the top sectoral loser on the BSE down 2.9% followed by Power, Capital Goods, Auto, Oil and Metal indices down 1-2.4% each.
In the Sensex pack, HDFC Bank continued to witness selling pressure and was among the top losers down 3.1%
Sensex ends below 19k level over growth concerns
Markets end lower amid weak global cues
Rupee up 23 paise against dollar on Budget hopes
RBI downplays money laundering charges
Markets end lower on political uncertainty