At the close the Sensex was down 239 points at 18,802 and the Nifty gave off 75 points to close at 5,673.
The broader too turned weak in the last hour trade, with the midcap index closing down 1% and the smallcap index weakened by 0.6%.
In Asia, Japan's Nikkei average jumped 3%, its biggest one-day rise in almost two months, on growing expectations that the central bank will announce further easing steps on Thursday.
The benchmark Nikkei rose to close at 12,362.
Hong Kong shares fell for a second day as lower oil prices pulled down the energy sector in thin trade ahead of a holiday break.
The Hang Seng Index closed down 0.1% at 22,337, its second loss in three days.
European shares and the euro eased while German bonds were flat as investors awaited this week's policy decisions by the Bank of Japan and European Central Bank followed by U.S. employment data.
Also, Cyprus's new Finance Minister Haris Georgiades was sworn in today following his predecessor's resignation hours after a probe was launched into how the island was pushed to the verge of bankruptcy.
London's FTSE, Paris's CAC-40 and Frankfurt's DAX all opened between 0.1-0.4% lower after equally strong gains on Tuesday.
Back home, selling pressure persisted across the sectors except Health Care which closed flat with a positive bias.
The sectoral indices which weighed in today's market were Realty, Auto, Capital Goods and Metal indices which lost between 2-2.7%.
Bankex, Oil & Gas, Consumer Durables, PSU and IT indices shed 1-1.8%
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