People magazine, citing representatives for the pair, reported that the two Hollywood actors split after more than a year together.
Aniston, the 37-year-old Friends star took up with Vaughn, 36, best known for comedies like The Wedding Crashers.
Vaughn and Aniston starred this summer in the comedy The Break-Up. Their union was the subject of speculation in the tabloid press, amid competing reports that they were either engaged or had called it quits.
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