The West Indies Cricket Board announced earlier on Wednesday that Taylor, 19, was returning home after failing to recover from a back strain sustained during the first Test against Zimbabwe in Harare last month.
West Indies chairman of selectors Viv Richards said in a statement issued in Antigua: "Judging from the word coming out of South Africa, and having regard for South Africa's vulnerability to wrist spinners, and having further regard for their (South Africa's) recent tour of Pakistan, it was felt among the selectors that a bit of variety would be needed."
"So, we're back-tracking from six quicks to a wrist spinner in Dave Mohammed as replacement. This, especially after (Dinanath) Ramnarine's successes against them."
Ramnarine announced recently that he was retiring from cricket.
West Indies, who beat a Nicky Oppenheimer XI by 12 runs in the opening match of their South African tour on Wednesday, will play South Africa in four Tests and five one-day internationals over the next two months.